Tuesday, July 28, 2020

WHEN MIGHT THE SARS-VOC-2 VACCINE BE

Vaccines have to go through at least 3 phases of testing, including preclinical studies and animal and human testing, to assess their safety, efficacy, side effects, and best method of application.

Given the global epidemiological crisis that we are experiencing, the increase in positive cases and the alarming number of deaths from COVID-19, humanity continues to be expectant in the face of the production of a vaccine that manages to control the disease and mitigate the effects of this pandemic. is causing in the world.

However, in some cases, it is a long and complex process that can take between 10 and 15 years and involves a combination of public and private efforts.

Researchers from the COVID-19 IBIO Volunteer group at the Universidad de los Andes, led by David Bigio, professor in the Department of Biomedical Engineering, created a series of graphic pieces that help to understand the phases that a vaccine must go through
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Phase 0 : Vaccines must go through preclinicals using tissue culture or cell culture systems and animal testing to assess their safety, immunogenicity, and response in humans. 

Phase 1: Tested in groups of 20 to 50 healthy people to confirm that it does not pose a health threat to identify side effects and determine the appropriate dose.

Phase 2: A larger-scale study involving 100 to 300 people is conducted to assess their short-term side effects, reaction to the immune system, and following this a vaccination schedule and method of application is proposed.

Phase 3:  Involves thousands of volunteers and compares the effects of the vaccine against those of a placebo (substance without pharmacological effect that is used as a control in a clinical trial) to evaluate how the vaccinated people evolve against those who do not. In this phase, statistical data about the effectiveness and safety of the vaccine are also collected.

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